JWH-313
JWH-313 is a synthetic cannabinoid that acts as a potent agonist at both the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-313 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The full chemical name is 1-(4-methoxynaphthalen-1-yl)-2-(1-pentylindol-3-yl)ethanone. The presence of the methoxy group on the naphthalene ring and the pentyl chain on the indole ring are significant for its binding affinity and activity at cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-313 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the therapeutic potential of CB2 receptor agonists, which are thought to have anti-inflammatory and immunomodulatory effects without the psychoactive effects associated with CB1 receptor activation.
Receptor Binding[edit | edit source]
- CB1 Receptor: JWH-313 binds to the CB1 receptor with moderate affinity, contributing to its psychoactive properties. - CB2 Receptor: It has a higher affinity for the CB2 receptor, which is primarily expressed in the immune system and peripheral tissues.
Potential Applications[edit | edit source]
Research into JWH-313 and similar compounds is ongoing to explore their potential therapeutic applications, particularly in the areas of pain management, inflammation, and neuroprotection. However, due to its classification as a synthetic cannabinoid, it is also subject to legal restrictions in many jurisdictions.
Legal Status[edit | edit source]
The legal status of JWH-313 varies by country. In many places, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-313 is not well-established. It is important for researchers to exercise caution and adhere to safety guidelines when handling this compound.
Also see[edit | edit source]
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