5F-PY-PINACA

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5F-PY-PINACA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system in the human body. This compound is structurally related to other synthetic cannabinoids such as AB-PINACA and 5F-AB-PINACA.

Chemical Structure and Properties

5F-PY-PINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure includes a 5-fluoropentyl chain attached to an indazole core, with a carboxamide linkage to a tert-leucine moiety. The presence of the fluorine atom in the pentyl chain is a common modification in synthetic cannabinoids, which often increases their potency and affinity for cannabinoid receptors.

Pharmacology

5F-PY-PINACA acts as a full agonist at the CB1 receptor and CB2 receptor, which are the primary targets of cannabinoids in the body. These receptors are G-protein coupled receptors that modulate neurotransmitter release in the brain. Activation of these receptors by 5F-PY-PINACA can lead to psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.

Effects and Toxicity

The effects of 5F-PY-PINACA can include euphoria, relaxation, altered perception, and increased appetite. However, due to its high potency, it can also cause severe adverse effects such as anxiety, paranoia, tachycardia, hypertension, and in some cases, seizures or psychosis. The toxicity of synthetic cannabinoids like 5F-PY-PINACA is a significant concern, as they can be much more potent than natural cannabinoids and have unpredictable effects.

Legal Status

The legal status of 5F-PY-PINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and other novel psychoactive substances.

Synthesis and Detection

The synthesis of 5F-PY-PINACA involves the reaction of an indazole core with a fluoropentyl chain and a carboxamide linkage. Detection of 5F-PY-PINACA in biological samples can be challenging due to its structural similarity to other synthetic cannabinoids. Advanced analytical techniques such as mass spectrometry and gas chromatography are often used for its identification.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Designer drugs
• AB-PINACA
• 5F-AB-PINACA