5F-PY-PICA
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5F-PY-PICA is a synthetic cannabinoid that has been used in scientific research and is a designer drug. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system in the human body. This compound is structurally related to other synthetic cannabinoids such as 5F-ADB and 5F-PB-22.
Chemical Structure and Properties[edit | edit source]
5F-PY-PICA is classified as an indole-based synthetic cannabinoid. Its chemical structure includes a 5-fluoropentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high potency. The compound's IUPAC name is 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indole-3-carboxamide, and it has a molecular formula of C23H26FN2O.
Pharmacology[edit | edit source]
5F-PY-PICA acts as a full agonist at the CB1 and CB2 receptors, which are the primary receptors of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood regulation, and appetite. The activation of these receptors by 5F-PY-PICA can lead to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the active component of cannabis.
Legal Status[edit | edit source]
The legal status of 5F-PY-PICA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. For example, it is listed as a Schedule I substance in the United States, meaning it is illegal to manufacture, distribute, or possess.
Health Effects and Risks[edit | edit source]
The use of 5F-PY-PICA has been associated with a range of adverse health effects. These can include tachycardia, hypertension, nausea, vomiting, and anxiety. In severe cases, it can lead to psychosis, seizures, and even death. The long-term health effects of using synthetic cannabinoids like 5F-PY-PICA are not well understood, but they are considered to be potentially harmful.
Research and Applications[edit | edit source]
While 5F-PY-PICA is primarily known as a recreational drug, it has also been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse and adverse effects, its use in research is highly regulated.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
