O-1624

A synthetic cannabinoid receptor agonist

O-1624 is a synthetic cannabinoid receptor agonist that has been used in scientific research to study the endocannabinoid system. It is a derivative of Δ9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure and Properties

O-1624 is chemically classified as a dibenzopyran derivative. Its structure is similar to that of THC, with modifications that enhance its affinity for cannabinoid receptors. The compound is characterized by the presence of a methoxy group at the 1-position and a dimethylheptyl side chain, which contribute to its potency and selectivity.

Pharmacology

O-1624 acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the G protein-coupled receptor family and are primarily involved in modulating neurotransmitter release in the brain. The activation of these receptors by O-1624 can lead to various physiological effects, including analgesia, anti-inflammatory responses, and modulation of mood and appetite.

Receptor Binding

Studies have shown that O-1624 has a high binding affinity for both CB1 and CB2 receptors, with a preference for CB1. This makes it a valuable tool for investigating the role of cannabinoid receptors in various biological processes.

Effects and Applications

Due to its potent activity at cannabinoid receptors, O-1624 is used in research to explore the therapeutic potential of cannabinoids. It has been studied in models of pain, inflammation, and neurodegenerative diseases. However, as a research chemical, it is not approved for medical use in humans.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of O-1624 is not well-established. It is important to handle this compound with caution in a laboratory setting, following appropriate safety protocols.

Legal Status

O-1624 is classified as a research chemical and is not approved for human consumption. Its legal status may vary by country, and researchers should ensure compliance with local regulations when conducting studies involving this compound.

Also see

• Cannabinoid receptor
• Endocannabinoid system
• Synthetic cannabinoids
• Δ9-tetrahydrocannabinol
• CB1 receptor
• CB2 receptor

Receptor Ligands
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Class	Not specified
Function	Not specified
Endogenous Ligands	None listed
Agonists	None listed
Antagonists	None listed
Partial Agonists	None listed
Inverse Agonists	None listed
Allosteric Modulators	None listed
Related Receptors	None listed