5Br-UR-144

5Br-UR-144_structure.png Chemical structure of 5Br-UR-144

5Br-UR-144 is a synthetic cannabinoid that has been used in scientific research and is known for its potent agonistic activity at the cannabinoid receptors CB1 and CB2. It is a brominated derivative of the compound UR-144, which is part of a class of compounds known as indole-based synthetic cannabinoids.

Chemical Structure and Properties

5Br-UR-144 is chemically classified as an indole-3-carboxamide. The compound features a bromine atom at the 5-position of the indole ring, which distinguishes it from its parent compound UR-144. The presence of the bromine atom is thought to influence the binding affinity and selectivity of the compound for cannabinoid receptors.

The molecular formula of 5Br-UR-144 is C₂₁H₂₈BrNO, and it has a molecular weight of 406.36 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

5Br-UR-144 acts as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system. These receptors are G protein-coupled receptors that play a role in various physiological processes, including pain sensation, mood regulation, and immune response.

The binding affinity of 5Br-UR-144 for the CB1 receptor is reported to be in the nanomolar range, indicating high potency. The compound's activity at the CB2 receptor is also significant, although it may exhibit some selectivity towards CB1.

Legal Status

The legal status of 5Br-UR-144 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects and abuse potential.

Research and Applications

5Br-UR-144 has been used in scientific research to study the effects of synthetic cannabinoids on the endocannabinoid system. Research involving this compound can provide insights into the pharmacological properties of cannabinoids and their potential therapeutic applications.

Health Effects and Safety

The health effects of 5Br-UR-144 in humans are not well-documented, as it is primarily used in research settings. However, synthetic cannabinoids as a class have been associated with a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis and organ damage.

Also see

• Synthetic cannabinoids
• CB1 receptor
• CB2 receptor
• UR-144
• Endocannabinoid system