5F-EDMB-PICA
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5F-EDMB-PICA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, specifically the CB1 receptor.
Chemical Structure and Properties[edit | edit source]
5F-EDMB-PICA belongs to the indole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 5-fluoropentyl chain attached to the indole core, with a methoxybenzyl group at the nitrogen atom of the indole. The presence of the fluorine atom in the pentyl chain is a common modification in synthetic cannabinoids, often used to increase potency and metabolic stability.
Pharmacology[edit | edit source]
5F-EDMB-PICA acts as a full agonist at the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids. The binding affinity and efficacy at the CB1 receptor are significant, leading to effects that mimic those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Effects[edit | edit source]
The effects of 5F-EDMB-PICA are similar to those of other synthetic cannabinoids and can include:
- Euphoria
- Altered perception
- Relaxation
- Anxiety or paranoia
- Tachycardia
- Nausea
Toxicity[edit | edit source]
The use of 5F-EDMB-PICA has been associated with adverse effects, including severe toxicity and even fatalities. Symptoms of overdose may include severe agitation, seizures, and cardiovascular complications.
Legal Status[edit | edit source]
The legal status of 5F-EDMB-PICA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use.
Synthesis[edit | edit source]
The synthesis of 5F-EDMB-PICA involves the reaction of 5-fluoropentylindole with 2-methoxybenzyl chloride in the presence of a base to form the carboxamide linkage. This synthetic route is similar to that of other indole-based synthetic cannabinoids.
Detection in Biological Samples[edit | edit source]
5F-EDMB-PICA can be detected in biological samples using techniques such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical toxicology to confirm exposure to the substance.
Also see[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
