JWH-229
| JWH-229_structure.png | |
JWH-229 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-229 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure is characterized by a naphthalene group attached to an indole core, with a methyl group at the 6-position of the indole ring. The full IUPAC name is (6aR,10aR)-3-(1-naphthalenylmethyl)-1,2,3,6,6a,7,10,10a-octahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran.
Pharmacology[edit | edit source]
JWH-229 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system, and its activation is associated with the psychoactive effects of cannabinoids. The CB2 receptor is mainly found in the immune system, and its activation is associated with anti-inflammatory effects.
Legal Status[edit | edit source]
The legal status of JWH-229 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, many synthetic cannabinoids, including JWH-229, are classified as Schedule I substances under the Controlled Substances Act.
Research and Applications[edit | edit source]
JWH-229, like other synthetic cannabinoids, was initially developed for research purposes to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. However, due to its psychoactive properties, it has also been used recreationally, often marketed as "herbal incense" or "spice."
Health Effects and Risks[edit | edit source]
The use of JWH-229 and other synthetic cannabinoids can pose significant health risks. These substances can cause a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and the presence of unknown adulterants in products containing synthetic cannabinoids further increase the risk of adverse effects.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
