JWH-336

JWH-336 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB1 and CB2 receptors. JWH-336 was developed by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-336 has the chemical formula C₂₈H₂₁NO and a molecular weight of 387.48 g/mol. The compound features a naphthoylindole core, which is a common structural motif in synthetic cannabinoids. The indole ring is substituted at the 3-position with a naphthalen-1-ylmethanone group, and the nitrogen atom of the indole is bonded to a 2,3-dihydro-1H-inden-1-yl group.

Pharmacology

JWH-336 is a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. The activation of these receptors by JWH-336 leads to a range of effects, including analgesia, sedation, and alterations in mood and perception. The compound's high potency and efficacy make it a valuable tool for studying the endocannabinoid system, although its use is limited to research settings due to its potential for abuse and lack of safety data in humans.

Legal Status

The legal status of JWH-336 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects. Researchers must obtain appropriate licenses to work with JWH-336 in countries where it is regulated.

Research Applications

JWH-336 is primarily used in scientific research to explore the pharmacological properties of cannabinoid receptors. Studies involving JWH-336 can help elucidate the mechanisms of action of cannabinoids and contribute to the development of new therapeutic agents targeting the endocannabinoid system.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-336 is not well-established. There is limited data on its toxicity, metabolism, and long-term effects. Researchers handling JWH-336 should follow strict safety protocols to minimize exposure and potential health risks.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• CB1 receptor
• CB2 receptor