Plantazolicin

Plantazolicin

Plantazolicin is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic produced by the soil bacterium Bacillus amyloliquefaciens FZB42. It is a member of the thiazole/oxazole-modified microcin (TOMM) family of natural products.

Structure and Biosynthesis

The structure of plantazolicin is characterized by a series of thiazole and (methyl)oxazole heterocycles, which are derived from cysteine, serine, and threonine residues via a post-translational modification (PTM) pathway. The biosynthesis of plantazolicin involves a precursor peptide, PznA, and several modification enzymes, including PznB, PznC, PznD, PznE, and PznF.

Mode of Action

Plantazolicin selectively inhibits the growth of Bacillus anthracis, the causative agent of anthrax. It achieves this by binding to the ribosome and blocking protein synthesis. The exact binding site and mechanism of action of plantazolicin are still under investigation.

Potential Applications

Due to its selective activity against Bacillus anthracis, plantazolicin has potential applications in the treatment of anthrax. However, further research is needed to fully understand its mechanism of action and to assess its safety and efficacy in clinical settings.

See Also

• Bacillus amyloliquefaciens
• Thiazole/oxazole-modified microcin
• Ribosomally synthesized and post-translationally modified peptide
• Antibiotic

References

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