Zincophorin
Zincophorin is a polyketide antibiotic that is produced by certain Streptomyces bacteria. It is known for its potent antibacterial activity and its unique structural features.
Structure[edit | edit source]
Zincophorin is a macrocyclic compound that contains a 20-membered ring. The ring is composed of a macrolide core, which is a common structural feature in many polyketide antibiotics. The macrolide core is decorated with several functional groups, including a methyl group, a hydroxyl group, and a carboxyl group. The presence of these functional groups contributes to the compound's antibacterial activity.
Biosynthesis[edit | edit source]
The biosynthesis of zincophorin involves a complex series of reactions that are catalyzed by a variety of enzymes. The process begins with the formation of the macrolide core, which is assembled by a polyketide synthase enzyme. This is followed by the addition of the functional groups, which are attached to the core by a series of tailoring enzymes.
Antibacterial Activity[edit | edit source]
Zincophorin exhibits potent antibacterial activity against a wide range of Gram-positive bacteria. It works by inhibiting the protein synthesis of the bacteria, thereby preventing their growth and proliferation. The compound's unique structure allows it to bind to the bacterial ribosome, which is the site of protein synthesis, and block the process.
Clinical Use[edit | edit source]
Despite its potent antibacterial activity, zincophorin is not currently used in clinical practice. This is primarily due to the compound's complex structure, which makes it difficult to synthesize in large quantities. However, research is ongoing to develop methods for the efficient production of zincophorin and other similar compounds, with the aim of expanding the arsenal of antibiotics available for the treatment of bacterial infections.
See Also[edit | edit source]
| This article is a stub. You can help WikiMD by registering to expand it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
