Δ8-iso-THC

Detailed article on Δ8-iso-THC

Δ8-iso-THC

File:Delta-8-iso-THC.svg
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PubChem	160569
ChemSpider	141050
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Chemical formula	C21H30NO2
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Δ8-iso-Tetrahydrocannabinol (Δ8-iso-THC) is a synthetic isomer of tetrahydrocannabinol (THC), the principal psychoactive constituent of the Cannabis plant. It is one of the many cannabinoids found in the cannabis plant, albeit in very small concentrations. Δ8-iso-THC is structurally similar to Δ9-THC, the most well-known form of THC, but differs in the position of a double bond in the cyclohexene ring.

Chemical Structure and Properties

Δ8-iso-THC is a terpenoid compound with the molecular formula C₁₁H₁₆O₂. It is a positional isomer of Δ9-THC, meaning it has the same molecular formula but a different arrangement of atoms. The double bond in Δ8-iso-THC is located at the 8th carbon position, as opposed to the 9th position in Δ9-THC. This slight difference in structure results in different pharmacological properties.

Pharmacology

Δ8-iso-THC interacts with the endocannabinoid system in the human body, primarily binding to the CB1 receptors in the central nervous system. This interaction is responsible for its psychoactive effects, which are generally considered to be less potent than those of Δ9-THC. The binding affinity of Δ8-iso-THC to CB1 receptors is lower than that of Δ9-THC, which may account for its reduced psychoactivity.

Synthesis

Δ8-iso-THC can be synthesized from cannabidiol (CBD) through a process of isomerization. This chemical reaction involves the rearrangement of the molecular structure of CBD to form Δ8-iso-THC. The synthesis of Δ8-iso-THC is typically carried out in a laboratory setting using acidic conditions to facilitate the isomerization process.

Legal Status

The legal status of Δ8-iso-THC varies by jurisdiction. In some regions, it is considered a controlled substance due to its structural similarity to Δ9-THC and its psychoactive properties. In other areas, it may be legal or unregulated. It is important to consult local laws and regulations regarding the use and distribution of Δ8-iso-THC.

Potential Applications

Research into the potential therapeutic applications of Δ8-iso-THC is ongoing. Some studies suggest that it may have antiemetic, anxiolytic, and appetite-stimulating effects. However, more research is needed to fully understand its pharmacological profile and potential medical uses.

Safety and Side Effects

The safety profile of Δ8-iso-THC is not well-established, and its use may be associated with side effects similar to those of Δ9-THC, including dizziness, dry mouth, and altered mental state. Users should exercise caution and consult healthcare professionals before using products containing Δ8-iso-THC.

Also see

• Cannabinoid
• Δ9-Tetrahydrocannabinol
• Cannabidiol
• Endocannabinoid system