CUMYL-CHMICA

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CUMYL-CHMICA

Drug Information
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Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data

CUMYL-CHMICA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the CB1 receptor, which is part of the endocannabinoid system in the human body. CUMYL-CHMICA is known for its psychoactive effects, which mimic those of THC, the active component of cannabis.

Chemical Structure and Properties

CUMYL-CHMICA belongs to the indole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 1-(4-cyanobutyl) group attached to the indole core, with an N-(2-phenylpropan-2-yl) substituent. The presence of the cyanobutyl group is a distinguishing feature of this compound.

The molecular formula of CUMYL-CHMICA is C₂₃H₂₅N₃O, and it has a molecular weight of 359.47 g/mol. The compound is typically found as a white powder and is soluble in organic solvents.

Pharmacology

CUMYL-CHMICA acts as a full agonist at the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids. The binding affinity of CUMYL-CHMICA to the CB1 receptor is high, leading to potent effects even at low doses. This high potency is a common characteristic of many synthetic cannabinoids, which can lead to severe adverse effects.

Effects and Toxicity

The effects of CUMYL-CHMICA are similar to those of other synthetic cannabinoids and include euphoria, altered perception, and relaxation. However, due to its high potency, it can also cause severe side effects such as anxiety, paranoia, tachycardia, and in some cases, psychosis.

Toxicological studies have shown that synthetic cannabinoids like CUMYL-CHMICA can lead to acute toxicity, with symptoms including nausea, vomiting, seizures, and in extreme cases, death. The long-term effects of CUMYL-CHMICA use are not well understood, but there is concern about potential neurotoxicity and other health risks.

Legal Status

The legal status of CUMYL-CHMICA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Regulatory agencies have been working to ban or restrict the sale and distribution of synthetic cannabinoids like CUMYL-CHMICA.

Synthesis

The synthesis of CUMYL-CHMICA involves the reaction of an indole-3-carboxylic acid derivative with a cyanobutyl halide, followed by the introduction of the N-(2-phenylpropan-2-yl) group. The synthesis requires careful control of reaction conditions to ensure the purity and yield of the final product.

Also see

• Synthetic cannabinoids
• CB1 receptor
• Cannabinoid receptor agonists
• Designer drugs