JWH-079

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JWH-079 is a synthetic cannabinoid that belongs to the naphthoylindole family. It is a chemical compound that acts as a potent agonist of the cannabinoid receptors, specifically the CB1 and CB2 receptors. JWH-079 is part of a series of compounds developed by Dr. John W. Huffman and his team at Clemson University in the 1990s and early 2000s for research purposes.

Chemical Structure and Properties

JWH-079 has the chemical formula C₂₄H₂₃NO and a molecular weight of 341.45 g/mol. The structure of JWH-079 consists of a naphthoyl group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. This structure is similar to other compounds in the JWH series, such as JWH-018 and JWH-073.

Pharmacology

JWH-079 acts as a full agonist at the CB1 and CB2 cannabinoid receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes, including pain sensation, mood regulation, and appetite. The binding affinity of JWH-079 for these receptors is similar to that of other synthetic cannabinoids, making it a potent psychoactive substance.

Legal Status

The legal status of JWH-079 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, synthetic cannabinoids like JWH-079 are often regulated under the Synthetic Drug Abuse Prevention Act of 2012, which places them in Schedule I of the Controlled Substances Act.

Potential Risks and Effects

The use of JWH-079, like other synthetic cannabinoids, can pose significant health risks. These substances can cause a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids increases the risk of contamination and unpredictable potency.

Research and Applications

JWH-079 and other synthetic cannabinoids have been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, due to their psychoactive properties and potential for abuse, their use is restricted to controlled laboratory settings.

Also see

• JWH-018
• JWH-073
• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system