JWH-160
| JWH-160_structure.png Chemical structure of JWH-160 | |
JWH-160 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds and was first synthesized by John W. Huffman and his team at Clemson University.
Chemical Structure and Properties[edit | edit source]
JWH-160 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound's IUPAC name is (2S)-2-(3-hydroxyphenyl)-1-(1-pentylindol-3-yl)ethanone. It has a molecular formula of C21H23NO2 and a molecular weight of 321.41 g/mol.
The structure of JWH-160 includes a pentyl chain attached to the indole core, which is a common feature among synthetic cannabinoids that contributes to their affinity for cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-160 acts as a full agonist at both the CB1 and CB2 receptors, which are part of the endocannabinoid system. The CB1 receptor is primarily found in the central nervous system, while the CB2 receptor is more common in peripheral tissues, particularly those involved in immune function.
The activation of these receptors by JWH-160 can lead to a variety of effects, including alterations in mood, perception, and cognition, as well as potential anti-inflammatory and analgesic effects.
Legal Status[edit | edit source]
The legal status of JWH-160 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is important to consult local regulations to determine the legal status of JWH-160 in a specific area.
Research and Applications[edit | edit source]
JWH-160, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potency and potential for adverse effects, its use is generally limited to controlled laboratory settings.
Safety and Toxicity[edit | edit source]
The safety profile of JWH-160 is not well-established, and its use outside of research settings is not recommended. Synthetic cannabinoids have been associated with a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
