JWH-204

JWH-204

JWH-204 is a synthetic cannabinoid that acts as a potent agonist for the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive properties. JWH-204 was developed in the early 2000s by Dr. John W. Huffman and his team at Clemson University as part of their research into the endocannabinoid system.

Chemical Structure and Properties

JWH-204 is chemically classified as a naphthoylindole. Its IUPAC name is 1-pentyl-3-(4-methyl-1-naphthoyl)indole. The molecular formula of JWH-204 is C25H25NO, and it has a molecular weight of 355.47 g/mol.

The structure of JWH-204 consists of a naphthalene ring system attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. This structure is similar to other compounds in the JWH series, which are known for their high affinity for cannabinoid receptors.

Pharmacology

JWH-204 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-204 for the CB1 receptor is high, which contributes to its potent psychoactive effects. The CB2 receptor, primarily found in the immune system, is also activated by JWH-204, although the implications of this activation are less well understood.

Legal Status

The legal status of JWH-204 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In the United States, JWH-204 and other synthetic cannabinoids have been placed under Schedule I of the Controlled Substances Act.

Potential Risks and Side Effects

The use of JWH-204, like other synthetic cannabinoids, can lead to a range of adverse effects. These may include anxiety, paranoia, tachycardia, and in severe cases, psychosis. The long-term health effects of JWH-204 are not well studied, but there is concern about its potential to cause harm due to its potency and the lack of regulation in its production.

Research and Applications

While JWH-204 itself is not used in clinical settings, research into synthetic cannabinoids like JWH-204 has provided valuable insights into the functioning of the endocannabinoid system. These compounds have been used as tools in scientific studies to better understand cannabinoid receptor interactions and the potential therapeutic applications of cannabinoids.

Also see

• JWH-018
• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system