JWH-225
| JWH-225_structure.png | |
JWH-225 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Structure and Properties[edit | edit source]
JWH-225 is chemically classified as a naphthoylindole, with the IUPAC name (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone. The compound has a molecular formula of C24H23NO and a molecular weight of 341.45 g/mol. The structure consists of a naphthalene group attached to a methanone bridge, which is further connected to an indole group.
Pharmacology[edit | edit source]
JWH-225 functions as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is more commonly associated with the immune system. The activation of these receptors by JWH-225 can lead to effects similar to those of THC, the primary psychoactive component of cannabis.
Legal Status[edit | edit source]
The legal status of JWH-225 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Research and Applications[edit | edit source]
JWH-225, like other synthetic cannabinoids, was initially synthesized for research purposes to better understand the endocannabinoid system and the role of cannabinoid receptors in the body. These compounds have been used in studies to explore the therapeutic potential of cannabinoids, including their effects on pain, inflammation, and neurological disorders.
Health Effects and Risks[edit | edit source]
The use of JWH-225 and other synthetic cannabinoids can pose significant health risks. These substances can produce severe adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and purity of synthetic cannabinoids increases the risk of overdose and other harmful outcomes.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
