JWH-253

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JWH-253 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-253 is chemically classified as a naphthoylindole, with the IUPAC name (2-(2-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone). The compound has a molecular formula of C₂₂H₂₅NO₂ and a molecular weight of 335.44 g/mol. The structure consists of a methoxyphenyl group attached to a pentylindole moiety via an ethanone linker.

Pharmacology

JWH-253 is known to bind to the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including mood, appetite, and pain sensation. JWH-253 has been shown to have a higher affinity for the CB1 receptor, which is primarily found in the central nervous system, compared to the CB2 receptor, which is more prevalent in peripheral tissues.

Legal Status

The legal status of JWH-253 varies by country. In some jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. In others, it may be legal or unregulated. Researchers must be aware of the legal implications of working with JWH-253 in their respective countries.

Research and Applications

JWH-253, like other synthetic cannabinoids, is primarily used in scientific research to better understand the endocannabinoid system and its role in health and disease. Studies involving JWH-253 can provide insights into the development of new therapeutic agents targeting cannabinoid receptors.

Safety and Toxicology

The safety profile of JWH-253 is not well-established, as it is primarily used in research settings. However, synthetic cannabinoids, in general, have been associated with adverse effects, including tachycardia, hypertension, and psychosis. Researchers should exercise caution and adhere to safety protocols when handling this compound.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• Cannabinoid receptor
• JWH-018
• JWH-073