JWH-261
JWH-261 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist of the cannabinoid receptors, specifically the CB1 receptor. JWH-261 is part of a series of compounds developed by Dr. John W. Huffman in the 1990s for research purposes.
Chemical Structure and Properties[edit | edit source]
JWH-261 has the chemical formula C₄H₂₃NO and a molecular weight of 341.45 g/mol. The structure consists of a naphthalenylmethanone core with a pentyl chain attached to the indole group. This configuration is typical of many synthetic cannabinoids, which are designed to mimic the effects of tetrahydrocannabinol (THC), the active component of cannabis.
Pharmacology[edit | edit source]
JWH-261 is a full agonist at the CB1 receptor, which is primarily found in the central nervous system. Activation of this receptor by JWH-261 can lead to effects similar to those of THC, including alterations in mood, perception, and cognition. The compound's affinity for the CB1 receptor is a key factor in its psychoactive properties.
Research and Applications[edit | edit source]
JWH-261, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and its role in various physiological processes. These studies help in understanding how cannabinoids interact with receptors in the body and can lead to the development of new therapeutic agents.
Legal Status[edit | edit source]
The legal status of JWH-261 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Researchers must obtain special licenses to work with this compound.
Safety and Toxicology[edit | edit source]
The safety profile of JWH-261 is not well-documented, as it is primarily used in research settings. However, synthetic cannabinoids in general have been associated with adverse effects, including tachycardia, hypertension, and psychosis. Caution is advised when handling these substances.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- John W. Huffman
- Endocannabinoid system
- Tetrahydrocannabinol
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