Lofexidine hydrochloride

Lofexidine Hydrochloride is a non-opioid medication used primarily in the management of opioid withdrawal. It is an alpha-2 adrenergic receptor agonist that works by reducing symptoms associated with opioid withdrawal such as anxiety, agitation, and restlessness.

Pharmacology

Lofexidine hydrochloride is an alpha-2 adrenergic receptor agonist. It works by binding to these receptors in the brain and inhibiting the release of norepinephrine, a neurotransmitter that plays a key role in the symptoms of opioid withdrawal. By reducing the release of norepinephrine, lofexidine hydrochloride can help to alleviate the physical symptoms associated with opioid withdrawal.

Clinical Use

Lofexidine hydrochloride is primarily used in the management of opioid withdrawal. It is often used in conjunction with other treatments, such as cognitive behavioral therapy and medication-assisted treatment, to help individuals overcome opioid addiction. It is also sometimes used off-label for the treatment of hypertension.

Side Effects

Common side effects of lofexidine hydrochloride include low blood pressure, slow heart rate, dizziness, and dry mouth. More serious side effects can include severe low blood pressure, slow heart rate, and fainting.

Contraindications

Lofexidine hydrochloride should not be used in individuals with severe heart disease, severe liver disease, or in those who are allergic to the medication. It should also be used with caution in individuals with low blood pressure or slow heart rate.

See Also

• Opioid withdrawal
• Alpha-2 adrenergic receptor
• Norepinephrine
• Cognitive behavioral therapy
• Medication-assisted treatment
• Hypertension