NNC 55-0396
NNC 55-0396 is a chemical compound known for its role as a selective blocker of T-type calcium channels. It is primarily used in research settings to study the physiological and pathological roles of these channels in various tissues.
Pharmacology[edit | edit source]
NNC 55-0396 is a derivative of mibefradil, a non-selective calcium channel blocker that was withdrawn from the market due to adverse interactions with other drugs. Unlike mibefradil, NNC 55-0396 is more selective for T-type calcium channels, which are low-voltage-activated channels involved in various cellular processes such as neuronal firing, muscle contraction, and hormone secretion.
Mechanism of Action[edit | edit source]
T-type calcium channels are involved in the pacemaking activity of the heart and the regulation of neuronal excitability. NNC 55-0396 inhibits these channels by binding to the alpha-1 subunit, thereby reducing calcium influx into the cell. This action can modulate electrical activity in neurons and cardiac cells, making it a valuable tool for studying conditions like epilepsy, cardiac arrhythmias, and pain.
Therapeutic Potential[edit | edit source]
While NNC 55-0396 is not used clinically, its ability to selectively block T-type calcium channels makes it a potential candidate for the development of new therapies for diseases such as epilepsy, hypertension, and neuropathic pain. Research is ongoing to explore its efficacy and safety in various preclinical models.
Research Applications[edit | edit source]
NNC 55-0396 is widely used in laboratory research to:
- Investigate the role of T-type calcium channels in neuronal plasticity and synaptic transmission.
- Study the effects of T-type calcium channel inhibition on cardiac electrophysiology.
- Explore potential therapeutic effects in models of chronic pain and epilepsy.
Safety and Toxicology[edit | edit source]
As a research compound, NNC 55-0396 is not approved for human use. Studies in animal models have shown that it can effectively block T-type calcium channels without the broad spectrum of effects seen with non-selective blockers like mibefradil. However, detailed toxicological profiles are necessary to assess its safety for potential therapeutic use.
Also see[edit | edit source]
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