Zabofloxacin

Zabofloxacin

Zabofloxacin is an antibacterial agent that belongs to the quinolone class of antibiotics. It is a broad-spectrum antibiotic that is primarily used in the treatment of bacterial infections caused by susceptible organisms.

History

Zabofloxacin was developed by Dong Wha Pharmaceuticals, a South Korean pharmaceutical company. The development of this antibiotic was part of a larger effort to combat the increasing prevalence of antibiotic resistance among bacterial pathogens.

Mechanism of Action

Zabofloxacin works by inhibiting the activity of DNA gyrase and topoisomerase IV, two enzymes that are essential for bacterial DNA replication. By inhibiting these enzymes, zabofloxacin prevents the bacteria from replicating and spreading, thereby helping to eliminate the infection.

Clinical Use

Zabofloxacin is primarily used in the treatment of community-acquired pneumonia and acute bacterial exacerbation of chronic bronchitis. It has shown to be effective against a wide range of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Side Effects

Like all antibiotics, zabofloxacin can cause side effects. The most common side effects include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause more serious side effects such as QT prolongation, a heart rhythm disorder.

Resistance

The development of resistance to zabofloxacin is a concern, as with all antibiotics. Resistance can occur when bacteria mutate or acquire resistance genes from other bacteria. To minimize the risk of resistance, it is important to use zabofloxacin and other antibiotics judiciously.

See Also

• Quinolone
• Antibiotic resistance
• DNA gyrase
• Topoisomerase IV

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