AM-4054

A synthetic cannabinoid

AM-4054 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds that are designed to mimic the effects of naturally occurring cannabinoids such as tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure and Properties

AM-4054 is chemically classified as an indole-based synthetic cannabinoid. Its IUPAC name is (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone. The compound features a fluorinated pentyl chain, which is a common modification in synthetic cannabinoids to enhance potency and metabolic stability.

The molecular formula of AM-4054 is C₂₃H₃₀FN₁O₁, and it has a molecular weight of approximately 355.49 g/mol. The presence of the fluorine atom in the pentyl chain is believed to contribute to its high affinity for the cannabinoid receptors.

Pharmacology

AM-4054 acts as a full agonist at the CB₁ and CB₂ cannabinoid receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including mood, appetite, pain sensation, and memory.

The binding affinity of AM-4054 for the CB₁ receptor is significantly higher than that of THC, making it a highly potent compound. This increased potency can lead to more pronounced psychoactive effects and a higher risk of adverse reactions.

Legal Status

The legal status of AM-4054 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is important for researchers and healthcare professionals to be aware of the legal implications of handling and studying this compound.

Potential Risks and Side Effects

As with other synthetic cannabinoids, the use of AM-4054 can be associated with a range of adverse effects. These may include:

• Psychiatric symptoms: Anxiety, paranoia, hallucinations, and psychosis.
• Cardiovascular effects: Tachycardia, hypertension, and in severe cases, myocardial infarction.
• Neurological effects: Seizures and cognitive impairment.

Due to these potential risks, the use of AM-4054 outside of a controlled research setting is not recommended.

Research and Applications

Research on AM-4054 is primarily focused on understanding its pharmacological properties and potential therapeutic applications. However, due to its high potency and risk profile, its use in clinical settings is limited.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol