CUMYL-NBMICA

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CUMYL-NBMICA

Drug Information
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Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data

CUMYL-NBMICA is a synthetic cannabinoid that has been identified in recreational drug products. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system.

Chemical Structure and Properties

CUMYL-NBMICA belongs to the indole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 1-(4-cyanobutyl) group attached to the indole core, with an N-(2-phenylpropan-2-yl) substituent. The presence of the cyanobutyl group is a distinguishing feature of this compound.

The molecular formula of CUMYL-NBMICA is C₂₃H₂₅N₃O, and it has a molecular weight of 359.47 g/mol. The compound is typically found as a white powder and is soluble in organic solvents.

Pharmacology

CUMYL-NBMICA acts as a full agonist at the CB1 receptor and CB2 receptor, which are G-protein coupled receptors involved in the modulation of neurotransmitter release. The activation of these receptors by CUMYL-NBMICA leads to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

The potency of CUMYL-NBMICA at these receptors is significantly higher than that of THC, which can lead to more pronounced psychoactive effects and a higher risk of adverse reactions. Users may experience effects such as euphoria, altered perception, and relaxation, but also anxiety, paranoia, and tachycardia.

Legal Status

The legal status of CUMYL-NBMICA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids as a class.

Health Risks and Toxicity

The use of CUMYL-NBMICA has been associated with a range of adverse health effects. These can include acute intoxication, cardiovascular complications, and neuropsychiatric symptoms. The long-term health effects of CUMYL-NBMICA use are not well understood, but there is concern about its potential for addiction and other chronic health issues.

Detection in Biological Samples

CUMYL-NBMICA can be detected in biological samples using techniques such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical toxicology to confirm exposure to the compound.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol