Cannabichromenic acid

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Cannabichromenic acid


Cannabichromenic acid (CBCA) is a cannabinoid found in the Cannabis plant. It is the precursor to cannabichromene (CBC), a compound that has significant medical potential.

Chemistry[edit | edit source]

CBCA is a carboxylic acid and is produced in the plant's trichomes through the conversion of cannabigerolic acid (CBGA) by the enzyme CBCA synthase. Upon decarboxylation, typically through heat, CBCA is converted into CBC.

Pharmacology[edit | edit source]

While the pharmacology of CBCA is not well-studied, its decarboxylated form, CBC, has been found to have several potential therapeutic effects. These include analgesic effects, anti-inflammatory effects, and antidepressant effects. It is also a weak cannabinoid receptor agonist.

Therapeutic potential[edit | edit source]

Research into the therapeutic potential of CBCA is in its early stages. However, its decarboxylated form, CBC, has shown promise in several areas. For example, it has been found to promote neurogenesis, the growth and development of nervous tissue. It also has potential as a treatment for acne due to its anti-inflammatory properties and its ability to reduce the production of sebum.

Legal status[edit | edit source]

The legal status of CBCA varies by country and is often tied to the legal status of cannabis. In many jurisdictions, it is legal when derived from hemp, a variety of cannabis that is low in tetrahydrocannabinol (THC).

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD