JWH-031
| JWH-031_structure.png | |
JWH-031 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and was developed by Dr. John W. Huffman in the 1990s for research purposes.
Chemical Structure and Properties[edit | edit source]
JWH-031 has the chemical formula C₁₁H₂₈N₂O₂ and a molecular weight of 340.46 g/mol. The structure consists of a 1-pentyl-1H-indol-3-yl group linked to a 2-morpholin-4-ylethyl methanone moiety. This configuration allows it to bind effectively to the CB1 and CB2 receptors in the endocannabinoid system.
Pharmacology[edit | edit source]
JWH-031 is a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the therapeutic potential of CB2 receptor agonists, which are thought to have anti-inflammatory and analgesic properties without the psychoactive effects associated with CB1 receptor activation.
Legal Status[edit | edit source]
The legal status of JWH-031 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Research and Applications[edit | edit source]
JWH-031 has been used in scientific research to study the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. Its selectivity for the CB2 receptor makes it a valuable tool in exploring the potential therapeutic applications of CB2 receptor agonists, such as in the treatment of pain, inflammation, and autoimmune diseases.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-031 is not well-established. It is known that synthetic cannabinoids can have unpredictable effects and may pose significant health risks, including cardiovascular and neurological effects. Research is ongoing to better understand the toxicological implications of JWH-031 and similar compounds.
Also see[edit | edit source]
- Synthetic cannabinoids
- Cannabinoid receptor
- Endocannabinoid system
- John W. Huffman
- CB1 receptor
- CB2 receptor
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