JWH-056

JWH-056

JWH-056 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is primarily used in scientific research to study the endocannabinoid system.

Chemical Structure and Properties

JWH-056 is chemically classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its full chemical name is 1-butyl-3-(2-methoxyphenylacetyl)indole. The compound has a molecular formula of C23H25NO2 and a molecular weight of 347.45 g/mol.

The structure of JWH-056 includes a core indole structure, which is a bicyclic compound consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. Attached to this core is a butyl chain and a methoxyphenylacetyl group, which contribute to its binding affinity and selectivity for cannabinoid receptors.

Pharmacology

JWH-056 acts as an agonist at the cannabinoid receptors, specifically the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, appetite, and memory.

The compound has been shown to have a higher affinity for the CB2 receptor compared to the CB1 receptor, which is a characteristic that distinguishes it from other synthetic cannabinoids. This selectivity makes JWH-056 a useful tool in research focused on the CB2 receptor and its potential therapeutic applications.

Research Applications

JWH-056 is primarily used in scientific research to explore the functions of the endocannabinoid system and the role of cannabinoid receptors in health and disease. Studies involving JWH-056 can help elucidate the mechanisms of action of cannabinoids and their potential therapeutic benefits.

Research on JWH-056 and similar compounds can contribute to the development of new treatments for conditions such as chronic pain, inflammation, and neurodegenerative diseases, where modulation of the endocannabinoid system may be beneficial.

Legal Status

The legal status of JWH-056 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Researchers must comply with local regulations when working with this compound.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-056 is not well-established. It is important for researchers to handle this compound with caution and to conduct studies in controlled environments to assess its pharmacological and toxicological effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• CB1 receptor
• CB2 receptor