JWH-070
| IUPAC Name: | (6aR,10aR)-3-(1-naphthylmethyl)-1,2,3,6,6a,7,10,10a-octahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran |
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JWH-070 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB1 and CB2 receptors. JWH-070 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-070 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The IUPAC name for JWH-070 is (6aR,10aR)-3-(1-naphthylmethyl)-1,2,3,6,6a,7,10,10a-octahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran. This compound has a molecular formula of C24H26O and a molecular weight of 330.47 g/mol.
Pharmacology[edit | edit source]
JWH-070 acts as a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. The activation of these receptors by JWH-070 leads to a range of physiological effects, including analgesia, anti-inflammatory effects, and modulation of neurotransmitter release. The compound's high potency and efficacy make it a subject of interest in both therapeutic research and the study of cannabinoid receptor function.
Legal Status[edit | edit source]
The legal status of JWH-070 varies by country. In the United States, it is classified as a Schedule I controlled substance under the Controlled Substances Act, meaning it is illegal to manufacture, distribute, or possess. Other countries have similar restrictions due to its potential for abuse and lack of accepted medical use.
Research and Applications[edit | edit source]
JWH-070 has been used in scientific research to better understand the role of cannabinoid receptors in the body. Its ability to selectively activate these receptors makes it a valuable tool in pharmacological studies. However, due to its legal status, research is often limited to controlled laboratory settings.
Safety and Toxicity[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-070 is not well-established. It is known that synthetic cannabinoids can have unpredictable effects and may pose significant health risks, including cardiovascular and neurological effects. Caution is advised when handling or studying this compound.
Also see[edit | edit source]
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