JWH-076

CaptionSynonyms

JWH-076

Drug Information
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Identifiers ATC Code DrugBank UNII KEGG ChEBI ChEMBL		Chemical Data N

JWH-076 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes but have since been used recreationally.

Chemical Structure and Properties

JWH-076 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure is characterized by a naphthalene group attached to an indole core, with a hydroxymethyl group and a dimethylheptyl side chain. The IUPAC name for JWH-076 is (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol.

Pharmacology

JWH-076 acts as a full agonist at the CB1 and CB2 cannabinoid receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, mood, and memory. The activation of these receptors by JWH-076 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Effects

The effects of JWH-076 are similar to those of other cannabinoids and can include euphoria, relaxation, altered perception of time, and increased appetite. However, due to its synthetic nature, the potency and duration of effects can vary significantly compared to natural cannabinoids. Users may also experience adverse effects such as anxiety, paranoia, and tachycardia.

Legal Status

The legal status of JWH-076 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is important to consult local regulations to determine its legal status in a specific area.

Research and Development

JWH-076 was initially developed for scientific research to study the cannabinoid receptors and the effects of their activation. It has been used in various studies to understand the pharmacological properties of synthetic cannabinoids and their potential therapeutic applications.

Safety and Toxicology

The safety profile of JWH-076 is not well-established, and its use is associated with potential health risks. As with other synthetic cannabinoids, there is a risk of overdose and severe adverse effects. Long-term health effects are not well understood, and caution is advised when handling or using this compound.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• Endocannabinoid system