JWH-080

JWH-080 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds and was first synthesized by John W. Huffman and his team at Clemson University.

Chemical Structure and Properties

JWH-080 is chemically classified as a naphthoylindole, with the IUPAC name (1-pentylindol-3-yl)-(2-methoxyphenyl)methanone. It has a molecular formula of C21H23NO2 and a molar mass of 321.41 g/mol. The structure consists of a pentyl chain attached to the indole core, which is linked to a methoxyphenyl group via a ketone bridge.

Pharmacology

JWH-080 is a potent agonist of the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the development of anti-inflammatory and analgesic agents that do not produce the psychoactive effects associated with CB1 receptor activation.

Mechanism of Action

JWH-080 binds to the cannabinoid receptors, mimicking the effects of naturally occurring endocannabinoids such as anandamide. Upon binding, it activates the receptors, leading to a cascade of intracellular events that modulate neurotransmitter release and produce various physiological effects.

Legal Status

The legal status of JWH-080 varies by country. In the United States, it is classified as a Schedule I controlled substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess. Other countries have similar restrictions due to its potential for abuse and lack of accepted medical use.

Research and Applications

JWH-080 has been used in scientific research to study the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. Its selectivity for the CB2 receptor makes it a valuable tool in exploring therapeutic targets for conditions such as chronic pain, inflammation, and autoimmune diseases.

Safety and Toxicity

As with many synthetic cannabinoids, the safety profile of JWH-080 is not well-established. It is known to produce effects similar to those of tetrahydrocannabinol (THC), including euphoria, altered perception, and potential for addiction. However, the full spectrum of its toxicological effects remains under investigation.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system