JWH-082

JWH-082 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073. JWH-082 was first synthesized by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-082 is chemically classified as a naphthoylindole, with the systematic name (1-pentyl-3-(4-methoxy-1-naphthoyl)indole). Its molecular formula is C25H25NO2, and it has a molecular weight of 371.47 g/mol. The compound features a methoxy group at the 4-position of the naphthoyl ring, which distinguishes it from other related compounds.

Pharmacology

JWH-082 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB2 receptor. This receptor selectivity is of interest in research contexts, as CB2 receptor agonists are being investigated for their potential therapeutic effects without the psychoactive effects associated with CB1 receptor activation.

Receptor Binding

- CB1 receptor: JWH-082 has a moderate affinity for the CB1 receptor, which is primarily found in the central nervous system. - CB2 receptor: JWH-082 exhibits a higher affinity for the CB2 receptor, which is predominantly expressed in the immune system and peripheral tissues.

Legal Status

The legal status of JWH-082 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. For example, in the United States, JWH-082 is listed as a Schedule I controlled substance under the Controlled Substances Act.

Research and Applications

JWH-082 has been used in scientific research to study the effects of cannabinoid receptor activation. Its selectivity for the CB2 receptor makes it a useful tool for investigating the role of this receptor in various physiological and pathological processes.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-082 is not well-established. It is known that synthetic cannabinoids can produce a range of adverse effects, including tachycardia, anxiety, hallucinations, and seizures. The long-term health effects of JWH-082 use are not well understood, and caution is advised when handling or studying this compound.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• JWH-073
• John W. Huffman