JWH-083

Synthetic cannabinoid

CaptionSynonyms

JWH-083

Drug Information
Image	200
Identifiers ATC Code DrugBank KEGG ChEBI ChEMBL		Chemical Data Molecular Weight

JWH-083 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-083 is chemically classified as a naphthoylindole, with the IUPAC name (1-pentylindol-3-yl)-1-naphthalenylmethanone. Its molecular formula is C₄H₂₃NO, and it has a molecular weight of 341.45 g/mol. The structure consists of a naphthalene group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole.

Pharmacology

JWH-083 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₁ receptor. This receptor is primarily found in the central nervous system, and its activation is associated with the psychoactive effects of cannabinoids. The CB₂ receptor is more commonly found in the immune system and is involved in modulating immune responses.

Effects and Usage

The effects of JWH-083 are similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Users may experience euphoria, altered perception, and relaxation. However, synthetic cannabinoids like JWH-083 can also cause adverse effects such as anxiety, paranoia, and tachycardia.

JWH-083 and other synthetic cannabinoids have been used recreationally, often sprayed onto plant material and smoked. They have been marketed under various brand names as "herbal incense" or "spice." Due to their potential for abuse and adverse health effects, many countries have moved to regulate or ban these substances.

Legal Status

The legal status of JWH-083 varies by country. In the United States, it is classified as a Schedule I controlled substance, making it illegal to manufacture, buy, possess, or distribute without a DEA license. Other countries have similar restrictions, reflecting concerns over its safety and potential for abuse.

Research and Development

JWH-083 was initially developed for scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in the body. Research into synthetic cannabinoids continues to provide insights into potential therapeutic applications, although the recreational use of these compounds poses significant public health challenges.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• Endocannabinoid system