JWH-095
Overview[edit | edit source]
JWH-095 is a synthetic cannabinoid that belongs to the naphthoylindole family. It was developed by Dr. John W. Huffman and his team at Clemson University as part of research into the endocannabinoid system. JWH-095 is known for its high affinity for the CB2 receptor, which is part of the endocannabinoid system in the human body.
Chemical Structure[edit | edit source]
JWH-095 is chemically classified as a naphthoylindole. Its full chemical name is 2-(1,1-dimethylheptyl)-1H-indol-3-yl](naphthalen-1-yl)methanone. The structure consists of a naphthalene group attached to an indole group, with a dimethylheptyl chain at the 2-position of the indole.
Pharmacology[edit | edit source]
JWH-095 acts as a potent agonist at the CB2 receptor, with a much lower affinity for the CB1 receptor. This selectivity makes it of interest for research into therapeutic applications that target the CB2 receptor, which is primarily associated with immune system modulation and anti-inflammatory effects.
Mechanism of Action[edit | edit source]
JWH-095 binds to the CB2 receptor, which is a G-protein coupled receptor. Upon binding, it activates intracellular signaling pathways that can lead to various physiological effects, including modulation of immune responses and potential anti-inflammatory effects.
Potential Applications[edit | edit source]
Due to its selectivity for the CB2 receptor, JWH-095 has been studied for potential applications in treating conditions such as chronic pain, inflammation, and autoimmune diseases. However, it is important to note that JWH-095 is primarily used in research settings and is not approved for medical use.
Legal Status[edit | edit source]
The legal status of JWH-095 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of approved medical use. Researchers must obtain appropriate licenses to study JWH-095 in a laboratory setting.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-095 is not well-established. It is important for researchers to exercise caution and follow appropriate safety protocols when handling this compound. Potential side effects and toxicological effects are not fully understood, and further research is needed to elucidate these aspects.
Also see[edit | edit source]
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