JWH-096

JWH-096 is a synthetic cannabinoid that acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were first synthesized by John W. Huffman and his team at Clemson University in the 1990s. JWH-096 is one of many compounds that have been used in scientific research to better understand the endocannabinoid system.

Chemical Structure and Properties

JWH-096 has the chemical formula C₂₅H₂₅NO₂ and a molecular weight of 371.47 g/mol. The structure consists of a naphthoyl group attached to an indole core, with a methoxy group at the 4-position of the naphthyl ring and a pentyl chain at the indole nitrogen.

Pharmacology

JWH-096 is a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. The activation of these receptors by JWH-096 leads to a variety of physiological effects, including modulation of neurotransmitter release, alteration of pain perception, and changes in mood and cognition. The compound's potency and efficacy at these receptors make it a valuable tool for studying the endocannabinoid system and the potential therapeutic applications of cannabinoid receptor modulation.

Research Applications

JWH-096 has been used in preclinical studies to investigate the role of cannabinoid receptors in various physiological and pathological processes. It has been employed in studies examining the effects of cannabinoids on pain, inflammation, appetite regulation, and neuroprotection. Additionally, JWH-096 and related compounds have been used to explore the potential therapeutic benefits of cannabinoids in conditions such as multiple sclerosis, cancer, and neurodegenerative diseases.

Legal Status

The legal status of JWH-096 varies by country. In some jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects. Researchers must be aware of the legal restrictions in their region when working with JWH-096.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-096 is not fully understood. While it is used in research settings, there is limited information on its long-term effects and potential toxicity in humans. Researchers should exercise caution and adhere to safety protocols when handling this compound.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• CB1 receptor
• CB2 receptor
• John W. Huffman