JWH-180
JWH-180 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.
Chemical Structure and Properties[edit | edit source]
JWH-180 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-pentyl-1H-indol-3-yl group attached to a 1-naphthalenylmethanone moiety. The presence of the naphthoyl group is characteristic of this class of compounds, which are known for their high affinity for cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-180 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite. The binding affinity of JWH-180 for these receptors is similar to that of other synthetic cannabinoids, making it a potent psychoactive compound.
Legal Status[edit | edit source]
Due to its potential for abuse and lack of medical use, JWH-180, like many other synthetic cannabinoids, has been classified as a controlled substance in several countries. The legal status of JWH-180 can vary significantly between jurisdictions, and it is often included in legislation targeting synthetic cannabinoids as a class.
Research and Applications[edit | edit source]
JWH-180, along with other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its psychoactive properties and potential for abuse, its use is generally restricted to controlled laboratory settings.
Health Effects and Risks[edit | edit source]
The use of synthetic cannabinoids like JWH-180 can pose significant health risks. These compounds can produce a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and the presence of unknown impurities in illicit preparations further increase the risk of harmful effects.
Also see[edit | edit source]
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