JWH-186
JWH-186 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist of the cannabinoid receptors, specifically the CB1 and CB2 receptors. JWH-186 is part of a series of compounds developed by Dr. John W. Huffman and his team at Clemson University in the 1990s and early 2000s.
Chemical Structure and Properties[edit | edit source]
JWH-186 has the chemical formula C25H23NO and a molecular weight of 353.46 g/mol. The structure consists of a naphthoyl group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. This structure is similar to other compounds in the JWH series, which are known for their high affinity for cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-186 functions as a full agonist at both the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as pain sensation, mood, and appetite. The activation of these receptors by JWH-186 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Legal Status[edit | edit source]
Due to its potential for abuse and lack of medical use, JWH-186, like many synthetic cannabinoids, has been subject to legal restrictions in various countries. In the United States, many compounds in the JWH series have been classified as Schedule I substances under the Controlled Substances Act.
Research and Applications[edit | edit source]
JWH-186, along with other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, its use is limited due to its psychoactive properties and potential for abuse.
Safety and Toxicity[edit | edit source]
The safety profile of JWH-186 is not well-documented, but synthetic cannabinoids are generally associated with a range of adverse effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of regulation and quality control in the production of these compounds further increases the risk of harmful effects.
Also see[edit | edit source]
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