JWH-189

JWH-189 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-189 is chemically classified as a naphthoylindole, with the IUPAC name (1-pentyl-3-(4-methoxyphenylacetyl)indole). Its molecular formula is C₂₃H₂₅N₁O₂, and it has a molecular weight of 347.45 g/mol. The compound features a pentyl chain attached to the indole core, which is a common structural motif in synthetic cannabinoids.

Pharmacology

JWH-189 is known to bind to the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₂ receptor. This selectivity makes it of interest in research focused on the therapeutic potential of CB₂ receptor agonists, which are thought to have anti-inflammatory and analgesic properties without the psychoactive effects associated with CB₁ receptor activation.

Research and Applications

JWH-189 has been used in scientific studies to explore the role of cannabinoid receptors in various physiological processes. Its ability to selectively activate CB₂ receptors has made it a valuable tool in the study of immune system modulation and potential treatments for inflammatory diseases.

Legal Status

The legal status of JWH-189 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with recreational use and potential health risks.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-189 is not well-established. It is important for researchers to exercise caution and adhere to safety guidelines when handling this compound in a laboratory setting.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• CB1 receptor
• CB2 receptor