JWH-190
JWH-190 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist at both the CB1 and CB2 cannabinoid receptors, with a slight selectivity for the CB2 receptor. JWH-190 is part of a series of compounds developed by Dr. John W. Huffman in the 1990s for research into the structure and function of the cannabinoid receptors.
Chemical Structure and Properties[edit | edit source]
JWH-190 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The full chemical name is (1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone. The compound has a molecular formula of C25H25NO and a molar mass of 355.48 g/mol.
Pharmacology[edit | edit source]
JWH-190 functions as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. The activation of these receptors by JWH-190 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Research and Development[edit | edit source]
JWH-190 was developed as part of a series of synthetic cannabinoids intended for research purposes. These compounds have been used to study the endocannabinoid system and to develop potential therapeutic agents. However, due to their potent effects and potential for abuse, many synthetic cannabinoids, including JWH-190, have been subject to legal restrictions in various countries.
Legal Status[edit | edit source]
The legal status of JWH-190 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to work with this compound.
Safety and Toxicology[edit | edit source]
The safety profile of JWH-190 has not been extensively studied in humans. However, synthetic cannabinoids have been associated with a range of adverse effects, including anxiety, paranoia, tachycardia, and in some cases, severe toxicity. Caution is advised when handling or studying this compound.
Also see[edit | edit source]
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