JWH-205
JWH-205 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Chemical Structure and Properties[edit | edit source]
JWH-205 is chemically classified as a naphthoylindole, with the IUPAC name (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone. The compound has a molecular formula of C23H21NO and a molar mass of 311.42 g/mol. Its structure consists of a naphthalene group attached to an indole core, which is further substituted with a propyl group at the nitrogen atom and a methyl group at the 2-position of the indole.
Pharmacology[edit | edit source]
JWH-205 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a crucial role in regulating various physiological processes including pain sensation, mood, appetite, and memory. The binding affinity of JWH-205 to these receptors is similar to that of other synthetic cannabinoids, making it a potent psychoactive substance.
Legal Status[edit | edit source]
The legal status of JWH-205 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Potential Risks and Effects[edit | edit source]
The use of JWH-205, like other synthetic cannabinoids, can lead to a range of adverse effects. These may include tachycardia, hypertension, anxiety, paranoia, and hallucinations. The long-term health effects of JWH-205 are not well-studied, but there is concern about its potential to cause neurotoxicity and other harmful effects.
Research and Applications[edit | edit source]
JWH-205 is primarily used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It is not approved for medical use in humans or animals.
Also see[edit | edit source]
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