JWH-207

{{Infobox chemical | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477002123 | ImageFile = JWH-207_structure.png | ImageSize = 200px | IUPACName = (4-methyl-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone | OtherNames = | Section1 = ! colspan=2 style="background: #f8eaba; text-align: center;" |Identifiers

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  Related Articles	Chemical substance • Chemistry • Molecule
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• Chemical Compound Information
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  Related Articles	Chemical substance • Chemistry • Molecule
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Chembox

JWH-207
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ChemSpider ID	[[ChemSpiderID|]]
Molecular Formula	[[Molecular formula|]]
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Chembox IUPHAR Ligand

JWH-207
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UNII	[[Unique Ingredient Identifier|]]
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PubChem CID

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  This template is designed to be used for creating a standardized information box for chemical compounds on WikiMD, similar to those found on WikiMD. It includes sections for identifiers, properties, hazards, and related compounds, with fields for various specific details such as PubChem ID, molecular formula, hazards, and more. Users can fill in the relevant information for the chemical compound they are documenting. The template also includes a stub notice encouraging users to expand the article, linking to the concept of a stub and the WikiMD project for further contributions.
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CompTox Dashboard (EPA )

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InChI

• InChI=1S/C25H25NO/c1-3-4-5-15-26-16-14-22(19-11-7-8-12-20(19)26)25(27)23-17-13-21(2)18-24(23)9-6-10-22/h7-13,16,18H,3-6,14-15H2,1-2H3

  Key: ZJZQXQZQZQZQZQ-UHFFFAOYSA-N

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SMILES

• CCCCCC1=CN(C2=CC=CC=C21)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C

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JWH-207 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB1 and CB2 receptors. JWH-207 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-207 is chemically classified as a naphthoylindole, with the IUPAC name (4-methyl-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone. It has a molecular formula of C25H25NO and a molar mass of 371.48 g/mol. The compound features a naphthalene ring system linked to an indole moiety via a ketone bridge, with a pentyl chain attached to the nitrogen atom of the indole.

Pharmacology

JWH-207 is a full agonist at both the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-207 leads to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

Due to its psychoactive properties and potential for abuse, JWH-207 has been classified as a Schedule I controlled substance in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use. In the United Kingdom, it is classified as a Class B drug, and in Canada, it is listed under Schedule II.

Research and Applications

JWH-207, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, due to its legal status, research is limited and highly regulated.

Health Effects and Risks

The use of JWH-207 and other synthetic cannabinoids has been associated with a range of adverse health effects, including tachycardia, hypertension, hallucinations, and psychosis. These effects are often more severe than those associated with natural cannabis, due to the high potency and full agonist activity of synthetic cannabinoids.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• CB1 receptor
• CB2 receptor