JWH-213

JWH-213

JWH-213 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is used primarily in scientific research to study the endocannabinoid system. This compound is of interest due to its high affinity for the CB1 and CB2 receptors, which are part of the body's endocannabinoid system.

Chemical Structure and Properties

JWH-213 is chemically classified as a naphthoylindole. Its full chemical name is (1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone. The compound has a molecular formula of C24H23NO and a molecular weight of 341.45 g/mol.

The structure of JWH-213 includes a naphthalene group attached to an indole core, with a pentyl chain at the nitrogen atom of the indole. This structure is similar to other synthetic cannabinoids, which often mimic the structure of naturally occurring cannabinoids such as THC.

Pharmacology

JWH-213 is a potent agonist of the CB1 and CB2 cannabinoid receptors. These receptors are part of the G-protein coupled receptor family and are primarily involved in the modulation of neurotransmitter release in the brain.

• CB1 Receptor: JWH-213 has a high affinity for the CB1 receptor, which is predominantly found in the central nervous system. Activation of this receptor by JWH-213 can lead to psychoactive effects similar to those produced by THC, the active component of cannabis.

• CB2 Receptor: JWH-213 also binds to the CB2 receptor, which is mainly located in the peripheral tissues and is involved in immune system modulation. The interaction with CB2 receptors is thought to contribute to the anti-inflammatory effects observed with cannabinoid use.

Research and Applications

JWH-213 is primarily used in research settings to study the effects of cannabinoid receptor activation. It helps in understanding the role of the endocannabinoid system in various physiological processes, including pain modulation, appetite regulation, and immune response.

Due to its potent activity, JWH-213 is often used in vitro and in vivo studies to explore the therapeutic potential of cannabinoids and to develop new drugs that target the endocannabinoid system.

Legal Status

The legal status of JWH-213 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Researchers must obtain special licenses to work with this compound.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-213 is not well-established. It is known to produce effects similar to those of THC, but with potentially greater potency and risk of adverse effects. These can include anxiety, paranoia, and cardiovascular effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• THC