JWH-227
JWH-227
JWH-227 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073.
Chemical Structure and Properties[edit | edit source]
JWH-227 has the chemical formula C25H25NO and a molecular weight of 355.48 g/mol. The compound is characterized by a naphthoylindole core structure, which is common among many synthetic cannabinoids. The full IUPAC name for JWH-227 is 1-pentyl-3-(2-methoxyphenylacetyl)indole.
Pharmacology[edit | edit source]
JWH-227 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB1 receptor. This receptor is primarily found in the central nervous system and is responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-227 can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of Cannabis.
Legal Status[edit | edit source]
The legal status of JWH-227 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In the United States, JWH-227 and other synthetic cannabinoids have been placed under Schedule I of the Controlled Substances Act.
Health Effects and Risks[edit | edit source]
The use of JWH-227, like other synthetic cannabinoids, can pose significant health risks. These compounds can cause a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and the lack of quality control in the production of synthetic cannabinoids further increase the risk of harmful effects.
Research and Applications[edit | edit source]
While JWH-227 and similar compounds have been used in scientific research to study the endocannabinoid system, their use outside of controlled laboratory settings is not recommended. Research has focused on understanding the binding affinity and activity of these compounds at cannabinoid receptors, which may contribute to the development of new therapeutic agents.
Also see[edit | edit source]
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