JWH-245

JWH-245 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-245 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-naphthalenylmethanone moiety linked to a 2-methyl-1-propyl-1H-indole group. The presence of the naphthoyl group is characteristic of many synthetic cannabinoids, contributing to their ability to bind to cannabinoid receptors.

The molecular formula of JWH-245 is C₂₃H₂₁NO, and it has a molar mass of 327.42 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-245 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-245 for the CB₁ receptor is high, which contributes to its potent psychoactive effects. The compound's interaction with the CB₂ receptor is also significant, although the physiological implications of this interaction are less well understood compared to CB₁ receptor activation.

Legal Status

The legal status of JWH-245 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. The compound is often included in legislation targeting synthetic cannabinoids, which are frequently sold as "legal highs" or "designer drugs."

Research and Applications

JWH-245, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, its use is limited due to safety concerns and the potential for abuse.

Health Effects and Risks

The use of JWH-245, particularly in unregulated settings, poses significant health risks. Adverse effects can include tachycardia, hypertension, hallucinations, and psychosis. Long-term effects are not well-documented, but there is concern about potential neurotoxicity and other harmful outcomes.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system