JWH-246

JWH-246 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-246 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-pentyl-1H-indol-3-yl group attached to a 1-naphthalenylmethanone moiety. The presence of the naphthoyl group is characteristic of this class of compounds, which are known for their high affinity for cannabinoid receptors.

The molecular formula of JWH-246 is C₂₅H₂₃NO, and it has a molar mass of 353.46 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-246 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-246 for the CB₁ receptor is high, which contributes to its potent psychoactive effects. The compound's interaction with the CB₂ receptor is also significant, although the physiological implications of this interaction are less well understood.

Legal Status

The legal status of JWH-246 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In the United States, synthetic cannabinoids like JWH-246 are often regulated under the Synthetic Drug Abuse Prevention Act of 2012, which places them in Schedule I of the Controlled Substances Act.

Potential Risks and Side Effects

The use of JWH-246, like other synthetic cannabinoids, can pose significant health risks. Adverse effects may include tachycardia, hypertension, hallucinations, and psychosis. Long-term use can lead to dependence and withdrawal symptoms.

Research and Applications

JWH-246, along with other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potential for abuse, its use is generally restricted to controlled laboratory settings.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system