JWH-248

Overview

JWH-248 is a synthetic cannabinoid that belongs to the naphthoylindole family. It is a chemical compound that acts as a potent agonist of the cannabinoid receptors, primarily the CB1 receptor and CB2 receptor. JWH-248 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the endocannabinoid system and the development of cannabinoid receptor ligands.

Chemical Structure and Properties

JWH-248 has the IUPAC name (1-pentyl-1H-indol-3-yl)(2-methoxyphenyl)methanone. Its molecular formula is C21H23NO2, and it has a molecular weight of 321.41 g/mol. The structure of JWH-248 consists of a naphthoyl group attached to an indole core, with a methoxyphenyl group at the 3-position of the indole.

Pharmacology

JWH-248 is known to bind to both the CB1 receptor and CB2 receptor, with a higher affinity for the CB1 receptor. This binding results in the activation of these receptors, which are part of the endocannabinoid system. The activation of CB1 receptors is primarily associated with psychoactive effects, while CB2 receptor activation is linked to anti-inflammatory and immunomodulatory effects.

Mechanism of Action

As a cannabinoid receptor agonist, JWH-248 mimics the action of naturally occurring endocannabinoids such as anandamide and 2-arachidonoylglycerol (2-AG). By binding to the CB1 and CB2 receptors, JWH-248 modulates neurotransmitter release in the brain and affects various physiological processes, including pain sensation, mood, and appetite.

Legal Status

The legal status of JWH-248 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is important to consult local regulations to determine the legal status of JWH-248 in a specific area.

Research and Applications

JWH-248, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its potent psychoactive effects and potential for abuse, its use is generally restricted to controlled laboratory settings.

Health Effects and Risks

The use of JWH-248, particularly in unregulated settings, poses significant health risks. These can include acute intoxication, cardiovascular effects, and potential for addiction. The long-term health effects of JWH-248 are not well understood, and its use is generally discouraged outside of research environments.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• CB1 receptor
• CB2 receptor