JWH-256

JWH-256

IUPAC Name:	(1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Other Names:
Identifiers
CAS Number
PubChem
ChemSpider
SMILES
InChI
InChIKey
StdInChI
StdInChIKey
Properties
Chemical formula	CHNO
Appearance
Density
Melting Point
Boiling Point
Solubility
Hazards
Main Hazards
Flash Point
Autoignition Temperature

JWH-256 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist of the cannabinoid receptors, specifically targeting the CB1 receptor. JWH-256 was developed by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-256 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-pentyl-1H-indol-3-yl group attached to a 1-naphthalenylmethanone moiety. The presence of the naphthoyl group is characteristic of this class of compounds, which are known for their high affinity for cannabinoid receptors.

The molecular formula of JWH-256 is C₂₅H₂₅NO, and it has a molar mass of 371.48 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-256 functions as a full agonist at the CB1 receptor, which is primarily located in the central nervous system. This receptor is responsible for mediating the psychoactive effects of cannabinoids. The activation of CB1 receptors by JWH-256 can lead to effects similar to those produced by tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

The potency and efficacy of JWH-256 at the CB1 receptor make it a subject of interest in both pharmacological research and forensic analysis. However, due to its synthetic nature and potential for abuse, JWH-256 is often included in the list of controlled substances in many jurisdictions.

Legal Status

The legal status of JWH-256 varies by country. In the United States, many synthetic cannabinoids, including those in the JWH series, have been classified as Schedule I substances under the Controlled Substances Act. This classification indicates that they have a high potential for abuse and no accepted medical use.

Research and Applications

JWH-256, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in the body. These studies can provide insights into potential therapeutic applications of cannabinoids, although the use of JWH-256 itself in clinical settings is limited due to its legal status and potential for adverse effects.

Health Effects and Risks

The use of synthetic cannabinoids such as JWH-256 can pose significant health risks. These compounds can produce a range of effects, including anxiety, paranoia, tachycardia, and in severe cases, psychosis. The variability in potency and the lack of quality control in illicit products further increase the risk of adverse effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole
• CB1 receptor