JWH-278

JWH-278

IUPAC Name:	(1-(4-methoxynaphthalen-1-yl)-2-(methylamino)propan-1-one)
Other Names:	JWH-278
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Chemical formula	CHNO
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JWH-278 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure and Properties

JWH-278 is chemically classified as a naphthoylindole, with the IUPAC name (1-(4-methoxynaphthalen-1-yl)-2-(methylamino)propan-1-one). It has a molecular formula of C15H17NO2 and a molar mass of 243.30 g/mol. The structure of JWH-278 includes a naphthalene ring system, which is a common feature in many synthetic cannabinoids, contributing to its binding affinity to cannabinoid receptors.

Pharmacology

JWH-278 acts as a full agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, and pain sensation. The activation of these receptors by JWH-278 can lead to effects similar to those produced by THC, such as euphoria, altered perception, and relaxation.

Legal Status

The legal status of JWH-278 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."

Safety and Toxicology

The safety profile of JWH-278 is not well-documented, as it is primarily used in research settings. However, synthetic cannabinoids in general have been associated with adverse effects such as anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of clinical data makes it difficult to fully assess the risks associated with JWH-278.

Research Applications

JWH-278 is used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. It serves as a tool for understanding the pharmacological properties of synthetic cannabinoids and their potential therapeutic applications.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• Tetrahydrocannabinol