JWH-299

Synonyms

JWH-299

Drug Information
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Identifiers ATC Code DrugBank UNII KEGG ChEBI ChEMBL		Chemical Data

JWH-299 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-299 is chemically classified as a naphthoylindole, with the IUPAC name (4-Methylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone. Its molecular formula is C₂₅H₂₅NO, and it has a molecular weight of 371.48 g/mol. The compound features a naphthalene ring system substituted with a methanone group, which is linked to an indole moiety.

Pharmacology

JWH-299 is a full agonist at the CB₁ and CB₂ cannabinoid receptors, with a higher affinity for the CB₂ receptor. This selectivity makes it of interest in research focused on the potential therapeutic applications of CB₂ receptor agonists, which are thought to have anti-inflammatory and immunomodulatory effects without the psychoactive effects associated with CB₁ receptor activation.

Research and Applications

JWH-299, like other synthetic cannabinoids, has been used in scientific research to better understand the endocannabinoid system and the role of cannabinoid receptors in various physiological processes. Its selective action on the CB₂ receptor makes it a valuable tool in studies investigating the potential for cannabinoid-based therapies in treating conditions such as chronic pain, inflammation, and autoimmune diseases.

Legal Status

The legal status of JWH-299 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects and abuse potential. Researchers must comply with regulatory requirements when working with JWH-299.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-299 is not well-established. It is important for researchers to exercise caution and adhere to safety protocols when handling this compound. Potential risks include psychoactive effects, cardiovascular issues, and other adverse reactions.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• CB1 receptor
• CB2 receptor