JWH-310

CaptionSynonyms

JWH-310

Drug Information
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Identifiers ATC Code DrugBank UNII KEGG ChEBI ChEMBL		Chemical Data

JWH-310 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which were originally developed for research purposes to study the endocannabinoid system.

Chemical Structure and Properties

JWH-310 is chemically classified as a naphthoylindole, with the IUPAC name (1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone. The compound consists of a naphthalene group attached to a methanone bridge, which is further connected to an indole group with a pentyl chain at the nitrogen atom. This structure is similar to other synthetic cannabinoids such as JWH-018 and JWH-073, but with variations in the side chain and core structure that affect its binding affinity and selectivity for cannabinoid receptors.

Pharmacology

JWH-310 is known to act as a full agonist at the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of particular interest in research focused on the therapeutic potential of CB2 receptor agonists, which are thought to have anti-inflammatory and immunomodulatory effects without the psychoactive effects associated with CB1 receptor activation.

Research and Applications

JWH-310 has been used in scientific studies to explore the role of cannabinoid receptors in various physiological processes. Its selective action on the CB2 receptor makes it a valuable tool for investigating the potential of CB2-targeted therapies in conditions such as chronic pain, inflammation, and autoimmune diseases.

Legal Status

The legal status of JWH-310 varies by country. In some jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with recreational use and potential health risks. Researchers must ensure compliance with local regulations when working with this compound.

Safety and Toxicology

As with many synthetic cannabinoids, the safety profile of JWH-310 is not well-established. Potential risks include adverse effects on the cardiovascular and central nervous systems, as well as the possibility of dependence and withdrawal symptoms. Caution is advised when handling and studying this compound.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• Endocannabinoid system