JWH-311
JWH-311 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073.
Chemical Structure and Properties[edit | edit source]
JWH-311 is chemically classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical formula is C24H23NO, and it has a molecular weight of 341.45 g/mol. The compound consists of a naphthalene group attached to an indole core, with a methoxyphenyl group at the 1-position of the indole.
Pharmacology[edit | edit source]
JWH-311 acts as a full agonist at the CB1 and CB2 cannabinoid receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the therapeutic potential of CB2 receptor agonists, which are thought to have anti-inflammatory and analgesic properties without the psychoactive effects associated with CB1 receptor activation.
Synthesis[edit | edit source]
The synthesis of JWH-311 involves the condensation of 1-naphthoyl chloride with 1-(4-methoxyphenyl)indole in the presence of a base. This reaction forms the naphthoylindole structure characteristic of the JWH series of synthetic cannabinoids.
Legal Status[edit | edit source]
The legal status of JWH-311 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids that have been associated with adverse health effects and abuse potential.
Potential Applications[edit | edit source]
Research into JWH-311 and similar compounds is ongoing, with studies exploring their potential use in treating conditions such as chronic pain, inflammation, and neurodegenerative diseases. However, the psychoactive effects and potential for abuse limit their use outside of controlled research settings.
Safety and Toxicology[edit | edit source]
The safety profile of JWH-311 is not well-established, and like other synthetic cannabinoids, it may pose significant health risks. Adverse effects reported with synthetic cannabinoids include tachycardia, hypertension, hallucinations, and psychosis.
Also see[edit | edit source]
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