JWH-341

JWH-341 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure and Properties

JWH-341 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The compound's full chemical name is (1-(2-(4-(1,1-dimethylheptyl)phenyl)ethyl)-3-(naphthalen-1-oyl)indole). It has a molecular formula of C₃₀H₃₅NO and a molecular weight of 425.6 g/mol.

The structure of JWH-341 includes a naphthalene group attached to an indole core, which is further substituted with a dimethylheptyl side chain. This structural configuration is crucial for its binding affinity and activity at the cannabinoid receptors.

Pharmacology

JWH-341 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-341 to the CB₁ receptor is similar to that of THC, making it a potent psychoactive compound. However, its effects can be more pronounced due to its full agonist activity, compared to THC's partial agonist activity.

Legal Status

The legal status of JWH-341 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."

Potential Risks and Side Effects

The use of JWH-341, like other synthetic cannabinoids, can lead to a range of adverse effects. These may include anxiety, paranoia, tachycardia, and in severe cases, psychosis. The lack of regulation and quality control in the production of synthetic cannabinoids further increases the risk of harmful side effects.

Research and Applications

While JWH-341 and similar compounds are primarily known for their recreational use, they have also been studied for potential therapeutic applications. Research into synthetic cannabinoids continues to explore their potential in pain management, neuroprotection, and as anti-inflammatory agents.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• JWH-018
• Tetrahydrocannabinol